DODMA

Product Name: DODMA
CAS No.: 104162-47-2
Chemical Name: DODMA
Synonyms: 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA);DODMA;R-DODMA;98.0% (TLC);2-amino-2,3-dimethyloleanol;2,3-Dioleyloxy-1-(dimethylamino)propane;1,2-Dioleyloxy-3-(dimethylamino)propane;2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC);N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine
CBNumber: CB02755573
Molecular Formula: C41H81NO2
Formula Weight: 620.09
MOL File: 104162-47-2.mol

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DODMA Property

Boiling point:: 649.7±55.0 °C(Predicted)
Density: 0.869±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in Ethanol, DMSO, DMF
pka: 8.65±0.28(Predicted)
BRN: 10139013
InChIKey: GLGLUQVVDHRLQK-WRBBJXAJSA-N
SMILES: C(N(C)C)C(OCCCCCCCC/C=C\CCCCCCCC)COCCCCCCCC/C=C\CCCCCCCC

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H336May cause drowsiness or dizziness

H351Suspected of causing cancer

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 53467
Product name: 2,3-Dioleyloxy-1-(dimethylamino)propane
Purity: ≥98.0% (TLC)
Packaging: 100mg
Price: $176
Updated: 2024/03/01

Sigma-Aldrich

Product number: 53467
Product name: 2,3-Dioleyloxy-1-(dimethylamino)propane
Purity: ≥98.0% (TLC)
Packaging: 500mg
Price: $697
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 50mg
Price: $55
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 100mg
Price: $99
Updated: 2024/03/01

Cayman Chemical

Product number: 15109
Product name: 1,2-Dioleyloxy-3-dimethylamino-propane
Purity: ≥98%
Packaging: 250mg
Price: $206
Updated: 2024/03/01

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DODMA Chemical Properties,Usage,Production

Description

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.

Chemical Properties

DODMA is a colourless to light yellow liquid; soluble in ethanol, DMSO, DMF; stored at -20℃.

Uses

1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical]

Uses

DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.

Application

DODMA is suitable for use in the preparation of lipid nanoparticles (LNPs).

Biochem/physiol Actions

DODMA (1,2-dioleyloxy-3-dimethylaminopropane) is used in the preparation of cationic liposomes and lipid nanoparticles (LNPs). LNPs with DODMA has low or neutral zeta potential. DODMA is efficient in encapsulating nucleic acid during synthesis by reducing the physiological pH. DODMA is implicated in gene therapy.

DODMA Preparation Products And Raw materials

Raw materials

Preparation Products

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DODMA Suppliers

China 72 United States 4 Global 76

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

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View Lastest Price from DODMA manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: DODMA 104162-47-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: DODMA 104162-47-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

104162-47-2, DODMARelated Search:

DOTAP Soy bean phospholipid Oleic acid SOY LECITHIN Lecithin Hydrogenated Cholesterol PG?(egg?PC) Cholesteryl sodium sulfate Egg phospholipids N-[1-(2,3-DIOLEYLOXY)PROPYL]-N,N,N-TRIMETHYLAMMONIUM CHLORIDE Sodium hyaluronate 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DiMyristoyl-sn-glycero-3-phospho-rac-(1-glycerol) SodiuM Salt 1,2-DI13-CIS-DOCOSENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

1,2-Dioleyloxy-3-(dimethylamino)propane

2,3-Dioleyloxy-1-(dimethylamino)propane

DODMA

N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine

2-amino-2,3-dimethyloleanol

1,2-Dioleyloxy-3-dimethylamino-propane (DODMA)

1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-

2,3-Dioleyloxy-1-(dimethylamino)propane >=98.0% (TLC)

1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-, (2S)-

N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine

R-DODMA

N,N-Dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-1-propanamine (2S)-

98.0% (TLC)

104162-47-2